Elimination reaction and isomerization reaction of DBU
Eliminate t he r eaction DBU has been used in a variety of elimination reactions to enable reagent molecules to introduce unsaturated bonds, as intermediates and raw materials for organic synthesis, and just a few examples are enough to see the application of DBU in elimination reactions. 1. Alkyl halides eliminate hydrogen halides A typical reaction is 1, 1-diiodobutane with an equal amount of DBU heated back to a brown solid, which is distilled and separated from the reaction mixture to produce the product (E) -1-iodo-1-butene with a yield of 80%. In general, it is difficult for DBU to dehalogenate vinyl halides to form alkynes, but the special structure of (E) -vinyl bromide and DBU is reflow in benzene, almost quantitatively converted to the corresponding alkynes, while the (Z) -isomer cannot undergo such a reaction. There are many examples of using DBU to dehalogenate halocarbons, which is enough to show that dbu reaction is a very effective reagent f...